Akey Lab

                   Princeton University


The Akey Lab is located in the Lewis-Sigler Institute for Integrative Genomics at Princeton University. Here you can find information about current research projects, present and past members of the lab, publications, and obtain software and supplementary data related to our work.

We are broadly interested in applying experimental, computational, and theoretical approaches to better understand the biology and evolution of genomes.

Our long-term goal is to address two fundamental and interrelated questions. First, what is the genetic architecture of phenotypic variation? Second, what is the mechanistic basis of evolutionary change? We are pursuing these questions in our three favorite "model" organisms: humans, dogs, and yeast.

In the news

  • New study identifies Neanderthal ancestry in African populations and describes its origin Princeton University
  • Africans, too, carry Neanderthal genetic legacy Science
  • Modern Africans and Europeans may have more Neanderthal ancestry than previously thought EurekAlert!
  • Bodies Keep Shrinking on This Island, and Scientists Aren't Sure Why New York Times
  • The Hunt for the Ancient ’Hobbit’s’ Modern Relatives National Geographic
  • The modern pygmies of Flores are not related to Homo floresiensis Ars Technica
  • Pygmy people in Indonesia not related to 'hobbit' but evolved short stature independently ABC News
  • Modern Flores Island pygmies show no genetic link to extinct ‘hobbits’ Princeton University
  • How Ancient Neanderthal DNA Still Influences Our Genes Today Smithsonian Magazine
  • The Neanderthal Inside Us BBC Inside Science
  • What Neanderthal DNA Is Doing To Your Genome SciShow
  • The Neanderthals, the Denisovans and Us New York Times
  • Rich sexual past between modern humans and Neandertals revealed Science
  • Ancestors of Modern Humans Interbred With Extinct Hominins, Study Finds New York Times
  • What did the Neanderthals do for us? BBC
  • Neanderthals Leave their Mark on Us New York Times
  • Neanderthal Genome Lives On in Modern Humans National Geographic News
  • Best Scientific Figures of 2012 Wired
  • Human Evolution Enters an Exciting New Phase Wired