Akey Lab

                   Princeton University


About us

The Akey Lab is located in the Lewis-Sigler Institute for Integrative Genomics at Princeton University. Here you can find information about current research projects, present and past members of the lab, publications, and obtain software and supplementary data related to our work.

We are broadly interested in applying experimental, computational, and theoretical approaches to better understand the biology and evolution of genomes.

Our long-term goal is to address two fundamental and interrelated questions. First, what is the genetic architecture of phenotypic variation? Second, what is the mechanistic basis of evolutionary change? We are pursuing these questions in our three favorite "model" organisms: humans, dogs, and yeast.

In the news

  • New study identifies Neanderthal ancestry in African populations and describes its origin
    Princeton University
  • Africans, too, carry Neanderthal genetic legacy
  • Modern Africans and Europeans may have more Neanderthal ancestry than previously thought
  • Bodies Keep Shrinking on This Island, and Scientists Aren't Sure Why
    New York Times
  • The Hunt for the Ancient ’Hobbit’s’ Modern Relatives
    National Geographic
  • The modern pygmies of Flores are not related to Homo floresiensis
    Ars Technica
  • Pygmy people in Indonesia not related to 'hobbit' but evolved short stature independently
    ABC News
  • Modern Flores Island pygmies show no genetic link to extinct ‘hobbits’
    Princeton University
  • How Ancient Neanderthal DNA Still Influences Our Genes Today
    Smithsonian Magazine
  • The Neanderthal Inside Us
    BBC Inside Science
  • What Neanderthal DNA Is Doing To Your Genome
  • The Neanderthals, the Denisovans and Us
    New York Times
  • Rich sexual past between modern humans and Neandertals revealed
  • Ancestors of Modern Humans Interbred With Extinct Hominins, Study Finds
    New York Times
  • What did the Neanderthals do for us?
  • Neanderthals Leave their Mark on Us
    New York Times
  • Neanderthal Genome Lives On in Modern Humans
    National Geographic News
  • Best Scientific Figures of 2012
  • Human Evolution Enters an Exciting New Phase